| Date | Location | Result | |
| 02/26/22 | Erie, PA | Slippery Rock 67, Mercyhurst 65 | Box score |
| 02/23/22 | Slippery Rock, PA | Edinboro 77, Slippery Rock 66 | Box score |
| 02/21/22 | California, PA (Convocation Center) | California (PA) 62, Slippery Rock 45 | Box score |
| 02/19/22 | Slippery Rock, PA | Gannon 73, Slippery Rock 47 | Box score |
| 02/16/22 | Slippery Rock, PA | Slippery Rock 75, Mercyhurst 73 (OT) | Box score |
| 02/14/22 | Indiana, Pa. (Kovalchick Complex) | Indiana (PA) 71, Slippery Rock 68 (2OT) | Box score |
| 02/12/22 | Greensburg, PA | Seton Hill 56, Slippery Rock 52 | Box score |
| 02/09/22 | Johnstown, PA | Pitt.-Johnstown 62, Slippery Rock 45 | Box score |
| 02/07/22 | Slippery Rock, PA | Seton Hill 60, Slippery Rock 45 | Box score |
| 02/05/22 | Slippery Rock, PA | Indiana (PA) 67, Slippery Rock 58 | Box score |
| 02/02/22 | Clarion, PA | Clarion 66, Slippery Rock 61 | Box score |
| 01/31/22 | Erie, PA | Gannon 74, Slippery Rock 62 | Box score |
| 01/29/22 | Slippery Rock, PA | California (PA) 66, Slippery Rock 45 | Box score |
| 01/26/22 | Millersville, PA | Millersville 76, Slippery Rock 66 (OT) | Box score |
| 01/22/22 | Edinboro, PA | Edinboro 71, Slippery Rock 55 | Box score |
| 01/08/22 | Slippery Rock, PA | Slippery Rock 65, Clarion 62 | Box score |
| 01/05/22 | Slippery Rock, PA | Slippery Rock 66, Pitt.-Johnstown 52 | Box score |
| 01/02/22 | Fairmont, WV | Slippery Rock 86, Fairmont St. 84 (2OT) | Box score |
| 12/19/21 | Slippery Rock, PA | Slippery Rock 57, West Chester 56 | Box score |
| 12/18/21 | Slippery Rock, PA | Kutztown 62, Slippery Rock 47 | Box score |
| 12/04/21 | Bloomsburg, PA | Bloomsburg 58, Slippery Rock 44 | Box score |
| 12/03/21 | Mansfield, PA | Slippery Rock 65, Mansfield 56 | Box score |
| 11/27/21 | Slippery Rock, PA | Slippery Rock 77, Notre Dame (OH) 71 (OT) | Box score |
| 11/24/21 | Slippery Rock, PA | Slippery Rock 73, East Stroudsburg 60 | Box score |
| 11/20/21 | Canton, OH | Slippery Rock 69, Malone 59 | Box score |
| 11/17/21 | Slippery Rock, PA | Slippery Rock 68, Ursuline 64 | Box score |
| 11/14/21 | Institute, WV | West Virginia State 84, Slippery Rock 71 | Box score |
| 11/13/21 | Institute, WV | Slippery Rock 84, Notre Dame (OH) 66 | Box score |